Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Previous preclinical work has demonstrated the therapeutic potential of antagonists of the group II metabotropic glutamate receptors (mGlus). Still, compounds that are selective for the individual group II mGlus (mGlu(2) and mGlu(3)) have been scarce. There remains a need for such compounds with the...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Engers, Julie L., Rodriguez, Alice L., Konkol, Leah C., Morrison, Ryan D., Thompson, Analisa D., Byers, Frank W., Blobaum, Anna L., Chang, Sichen, Venable, Daryl F., Loch, Matthew T., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809247/
https://ncbi.nlm.nih.gov/pubmed/26335039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01005
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