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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)
Development of SAR in an octahydropyrrolo[3,4-c]pyrrole series of negative allosteric modulators of mGlu(1) using a functional cell-based assay is described in this Letter. The octahydropyrrolo[3,4-c]pyrrole scaffold was chosen as an isosteric replacement for the piperazine ring found in the initial...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3901432/ https://ncbi.nlm.nih.gov/pubmed/23932792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.029 |
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