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Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Both orthosteric and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus) have been used to establish a link between mGlu(2/3) inhibition and a variety of CNS diseases and disorders. Though these tools typically have good selectivity for mGlu(2/3) versus the remaining six...

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Библиографические подробности
Опубликовано в: :J Med Chem
Главные авторы: Felts, Andrew S., Rodriguez, Alice L., Smith, Katrina A., Engers, Julie L., Morrison, Ryan D., Byers, Frank W., Blobaum, Anna L., Locuson, Charles W., Chang, Sichen, Venable, Daryl F., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817271/
https://ncbi.nlm.nih.gov/pubmed/26524606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01371
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