VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu(5)) have potential applications in the treatment of fragile X syndrome, levodopa-induced dyskinesia in Parkinson disease, Alzheimer disease, addiction, and anxiety; however, clinical and preclinical studies rais...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Nickols, Hilary Highfield, Yuh, Joannes P., Gregory, Karen J., Morrison, Ryan D., Bates, Brittney S., Stauffer, Shaun R., Emmitte, Kyle A., Bubser, Michael, Peng, Weimin, Nedelcovych, Michael T., Thompson, Analisa, Lv, Xiaohui, Xiang, Zixiu, Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702078/
https://ncbi.nlm.nih.gov/pubmed/26503377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.226597
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