Centrally Active Allosteric Potentiators of the M(4) Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

Previous clinical and animal studies suggest that selective activators of M(1) and/or M(4) muscarinic acetylcholine receptors (mAChRs) have potential as novel therapeutic agents for treatment of schizophrenia and Alzheimer’s disease. However, highly selective centrally penetrant activators of either...

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Hauptverfasser: Brady, Ashley E., Jones, Carrie K., Bridges, Thomas M., Kennedy, J. Phillip, Thompson, Analisa D., Heiman, Justin U., Breininger, Micah L., Gentry, Patrick R., Yin, Huiyong, Jadhav, Satyawan B., Shirey, Jana K., Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745822/
https://ncbi.nlm.nih.gov/pubmed/18772318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.140350
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