A Selective Allosteric Potentiator of the M(1) Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning

M(1) muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a major limitation to testing this hypothesis has been a lack of highly selective ligands for individual mAChR subtypes. We now report the rigorou...

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Main Authors: Shirey, Jana K., Brady, Ashley E., Jones, Paulianda J., Davis, Albert A., Bridges, Thomas M., Kennedy, J. Phillip, Jadhav, Satyawan B., Menon, Usha N., Xiang, Zixiu, Watson, Mona L., Christian, Edward P., Doherty, James J., Quirk, Michael C., Snyder, Dean H., Lah, James J., Levey, Allan I., Nicolle, Michelle M., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811323/
https://ncbi.nlm.nih.gov/pubmed/19906975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3930-09.2009
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