Novel Selective Allosteric Activator of the M(1) Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously developed muscarinic agonists have provided clin...

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Главные авторы: Jones, Carrie K., Brady, Ashley E., Davis, Albert A., Xiang, Zixiu, Bubser, Michael, Tantawy, Mohammed Noor, Kane, Alexander S., Bridges, Thomas M., Kennedy, J. Phillip, Bradley, Stefania R., Peterson, Todd E., Ansari, M. Sib, Baldwin, Ronald M., Kessler, Robert M., Deutch, Ariel Y., Lah, James J., Levey, Allan I., Lindsley, Craig W., Conn, P. Jeffrey
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577155/
https://ncbi.nlm.nih.gov/pubmed/18842902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1850-08.2008
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