Novel Selective Allosteric Activator of the M(1) Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously developed muscarinic agonists have provided clin...

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Main Authors: Jones, Carrie K., Brady, Ashley E., Davis, Albert A., Xiang, Zixiu, Bubser, Michael, Tantawy, Mohammed Noor, Kane, Alexander S., Bridges, Thomas M., Kennedy, J. Phillip, Bradley, Stefania R., Peterson, Todd E., Ansari, M. Sib, Baldwin, Ronald M., Kessler, Robert M., Deutch, Ariel Y., Lah, James J., Levey, Allan I., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577155/
https://ncbi.nlm.nih.gov/pubmed/18842902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1850-08.2008
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