Differential Effects of Allosteric M(1) Muscarinic Acetylcholine Receptor Agonists on Receptor Activation, Arrestin 3 Recruitment, and Receptor Downregulation

[Image: see text] Muscarinic acetylcholine receptors (mAChRs) are drug targets for multiple neurodegenerative and neuropsychiatric disorders, but the full therapeutic potential of mAChR-targeted drugs has not been realized, mainly because of a lack of subtype-selective agonists. Recent advances have...

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Detalhes bibliográficos
Main Authors: Davis, Albert A., Heilman, Craig J., Brady, Ashley E., Miller, Nicole R., Fuerstenau-Sharp, Maya, Hanson, Bonnie J., Lindsley, Craig W., Conn, P. Jeffrey, Lah, James J., Levey, Allan I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936488/
https://ncbi.nlm.nih.gov/pubmed/20835371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100011e
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