Antipsychotic Drug-Like Effects of the Selective M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Accumulating evidence suggests that selective M(4) muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy for the treatment of psychosis. However, previous efforts to develop selective M(4) activators were unsuccessful because of the lack of M(4) mAChR subtype specificity an...

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Main Authors: Byun, Nellie E, Grannan, Michael, Bubser, Michael, Barry, Robert L, Thompson, Analisa, Rosanelli, John, Gowrishankar, Raajaram, Kelm, Nathaniel D, Damon, Stephen, Bridges, Thomas M, Melancon, Bruce J, Tarr, James C, Brogan, John T, Avison, Malcolm J, Deutch, Ariel Y, Wess, Jürgen, Wood, Michael R, Lindsley, Craig W, Gore, John C, Conn, P Jeffrey, Jones, Carrie K
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023154/
https://ncbi.nlm.nih.gov/pubmed/24442096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.2
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