Antipsychotic Drug-Like Effects of the Selective M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Accumulating evidence suggests that selective M(4) muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy for the treatment of psychosis. However, previous efforts to develop selective M(4) activators were unsuccessful because of the lack of M(4) mAChR subtype specificity an...

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Detalhes bibliográficos
Main Authors: Byun, Nellie E, Grannan, Michael, Bubser, Michael, Barry, Robert L, Thompson, Analisa, Rosanelli, John, Gowrishankar, Raajaram, Kelm, Nathaniel D, Damon, Stephen, Bridges, Thomas M, Melancon, Bruce J, Tarr, James C, Brogan, John T, Avison, Malcolm J, Deutch, Ariel Y, Wess, Jürgen, Wood, Michael R, Lindsley, Craig W, Gore, John C, Conn, P Jeffrey, Jones, Carrie K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023154/
https://ncbi.nlm.nih.gov/pubmed/24442096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.2
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