Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M(4) PAM VU0467154

Although selective activation of the M(1) muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of neuropsychiatric disorders, recent evidence suggests that enhancing M(4) mAChR function can also improve memory performance. Positive allosteri...

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Publicado en:Neuropharmacology
Autores principales: Gould, Robert W., Grannan, Michael D., Gunter, Barak W., Ball, Jacob, Bubser, Michael, Bridges, Thomas M., Wess, Jurgen, Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756753/
https://ncbi.nlm.nih.gov/pubmed/28729220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.07.013
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