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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disordersw

Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the treatment of multiple CNS disorders. The high degree of conservation of amino acids comprising the orthosteric acetylcholine (ACh) binding site between individual mAChR subtypes has hindered the development of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biosyst
Prif Awduron: Digby, Gregory J., Shirey, Jana K., Conn, P. Jeffrey
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780333/
https://ncbi.nlm.nih.gov/pubmed/20582339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c002938f
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