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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Despite G-protein-coupled receptors (GPCRs) being among the most fruitful targets for marketed drugs, intense discovery efforts for several GPCR subtypes have failed to deliver selective drug candidates. Historically, drug discovery programmes for GPCR ligands have been dominated by efforts to devel...

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Bibliografske podrobnosti
Main Authors: Conn, P. Jeffrey, Christopoulos, Arthur, Lindsley, Craig W.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907734/
https://ncbi.nlm.nih.gov/pubmed/19116626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2760
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