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Development of allosteric modulators of GPCRs for treatment of CNS disorders

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a promising new strategy with potential for developing novel treatments for a variety of central nervous system (CNS) disorders. Traditional drug discovery efforts targeting GPCRs have focused on developing ligand...

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Hlavní autoři: Nickols, Hilary Highfield, Conn, P. Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875303/
https://ncbi.nlm.nih.gov/pubmed/24076101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.09.013
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