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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Despite G-protein-coupled receptors (GPCRs) being among the most fruitful targets for marketed drugs, intense discovery efforts for several GPCR subtypes have failed to deliver selective drug candidates. Historically, drug discovery programmes for GPCR ligands have been dominated by efforts to devel...

詳細記述

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書誌詳細
主要な著者: Conn, P. Jeffrey, Christopoulos, Arthur, Lindsley, Craig W.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907734/
https://ncbi.nlm.nih.gov/pubmed/19116626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2760
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