Discovery and Characterization of Novel Allosteric Potentiators of M(1) Muscarinic Receptors Reveals Multiple Modes of Activity

Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M(1)-active compounds has resulted in nonselective activation of the highly related M(2) to M(5) mAChR subtypes, which results...

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Main Authors: Marlo, Joy E., Niswender, Colleen M., Days, Emily L., Bridges, Thomas M., Xiang, Yun, Rodriguez, Alice L., Shirey, Jana K., Brady, Ashley E., Nalywajko, Tasha, Luo, Qingwei, Austin, Cheryl A., Williams, Michael Baxter, Kim, Kwangho, Williams, Richard, Orton, Darren, Brown, H. Alex, Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684909/
https://ncbi.nlm.nih.gov/pubmed/19047481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052886
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