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Discovery and Characterization of Novel Allosteric Potentiators of M(1) Muscarinic Receptors Reveals Multiple Modes of Activity
Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M(1)-active compounds has resulted in nonselective activation of the highly related M(2) to M(5) mAChR subtypes, which results...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684909/ https://ncbi.nlm.nih.gov/pubmed/19047481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052886 |
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