Discovery and Characterization of Novel Allosteric Potentiators of M(1) Muscarinic Receptors Reveals Multiple Modes of Activity

Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M(1)-active compounds has resulted in nonselective activation of the highly related M(2) to M(5) mAChR subtypes, which results...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Marlo, Joy E., Niswender, Colleen M., Days, Emily L., Bridges, Thomas M., Xiang, Yun, Rodriguez, Alice L., Shirey, Jana K., Brady, Ashley E., Nalywajko, Tasha, Luo, Qingwei, Austin, Cheryl A., Williams, Michael Baxter, Kim, Kwangho, Williams, Richard, Orton, Darren, Brown, H. Alex, Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Pharmacology and Experimental Therapeutics 2009
الموضوعات:
Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684909/
https://ncbi.nlm.nih.gov/pubmed/19047481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052886
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