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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4

Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia. Activation of metabotropic glutamate receptor 4 (mGluR4) has been shown to modulate neurotransmission in the basal ganglia and results in antip...

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Detalhes bibliográficos
Main Authors: Niswender, Colleen M., Johnson, Kari A., Weaver, C. David, Jones, Carrie K., Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L., Marlo, Joy E., de Paulis, Tomas, Thompson, Analisa D., Days, Emily L., Nalywajko, Tasha, Aust, Cheryl A., Williams, Michael Baxter, Ayala, Jennifer E., Williams, Richard, Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574552/
https://ncbi.nlm.nih.gov/pubmed/18664603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.049551
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