Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4

Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia. Activation of metabotropic glutamate receptor 4 (mGluR4) has been shown to modulate neurotransmission in the basal ganglia and results in antip...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Niswender, Colleen M., Johnson, Kari A., Weaver, C. David, Jones, Carrie K., Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L., Marlo, Joy E., de Paulis, Tomas, Thompson, Analisa D., Days, Emily L., Nalywajko, Tasha, Aust, Cheryl A., Williams, Michael Baxter, Ayala, Jennifer E., Williams, Richard, Lindsley, Craig W., Conn, P. Jeffrey
التنسيق: Artigo
اللغة:Inglês
منشور في: 2008
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574552/
https://ncbi.nlm.nih.gov/pubmed/18664603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.049551
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