Discovery and Characterization of Novel Allosteric Potentiators of M(1) Muscarinic Receptors Reveals Multiple Modes of Activity

Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M(1)-active compounds has resulted in nonselective activation of the highly related M(2) to M(5) mAChR subtypes, which results...

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主要な著者: Marlo, Joy E., Niswender, Colleen M., Days, Emily L., Bridges, Thomas M., Xiang, Yun, Rodriguez, Alice L., Shirey, Jana K., Brady, Ashley E., Nalywajko, Tasha, Luo, Qingwei, Austin, Cheryl A., Williams, Michael Baxter, Kim, Kwangho, Williams, Richard, Orton, Darren, Brown, H. Alex, Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Pharmacology and Experimental Therapeutics 2009
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684909/
https://ncbi.nlm.nih.gov/pubmed/19047481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052886
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