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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disordersw

Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the treatment of multiple CNS disorders. The high degree of conservation of amino acids comprising the orthosteric acetylcholine (ACh) binding site between individual mAChR subtypes has hindered the development of...

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Bibliografiset tiedot
Julkaisussa:Mol Biosyst
Päätekijät: Digby, Gregory J., Shirey, Jana K., Conn, P. Jeffrey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780333/
https://ncbi.nlm.nih.gov/pubmed/20582339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c002938f
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