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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disordersw

Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the treatment of multiple CNS disorders. The high degree of conservation of amino acids comprising the orthosteric acetylcholine (ACh) binding site between individual mAChR subtypes has hindered the development of...

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Detalles Bibliográficos
Publicado en:Mol Biosyst
Main Authors: Digby, Gregory J., Shirey, Jana K., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780333/
https://ncbi.nlm.nih.gov/pubmed/20582339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c002938f
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