Activation and allosteric modulation of a muscarinic acetylcholine receptor

Despite recent advances in crystallography of G protein-coupled receptors (GPCRs), little is known about the mechanism of their activation process, as only the β(2) adrenergic receptor (β(2)AR) and rhodopsin have been crystallized in fully active conformations. Here, we report the structure of an ag...

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Hlavní autoři: Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020789/
https://ncbi.nlm.nih.gov/pubmed/24256733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12735
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