Impact of species variability and ‘probe-dependence’ on the detection and in vivo validation of allosteric modulation at the M(4) muscarinic acetylcholine receptor

BACKGROUND AND PURPOSE: We recently characterized LY2033298 as a novel allosteric modulator and agonist at M(4) muscarinic acetylcholine receptors (mAChRs). Evidence also suggested a difference in the potency of LY2033298 at rodent relative to human M(4) mAChRs. The current study investigated the ba...

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Main Authors: Suratman, S, Leach, K, Sexton, PM, Felder, CC, Loiacono, RE, Christopoulos, A
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2011
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057301/
https://ncbi.nlm.nih.gov/pubmed/21198541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01184.x
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