Structural Determinants of Allosteric Agonism and Modulation at the M(4) Muscarinic Acetylcholine Receptor: IDENTIFICATION OF LIGAND-SPECIFIC AND GLOBAL ACTIVATION MECHANISMS

The recently identified small molecule, 3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylic acid cyclopropylamide (LY2033298), is the first selective allosteric modulator of the muscarinic acetylcholine receptors (mAChRs) that mediates both receptor activation and positive modulati...

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Hlavní autoři: Nawaratne, Vindhya, Leach, Katie, Felder, Christian C., Sexton, Patrick M., Christopoulos, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885178/
https://ncbi.nlm.nih.gov/pubmed/20406819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125096
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