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Allosteric Modulation of M(1) Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking

Allosteric modulators are an attractive approach to achieve receptor subtype-selective targeting of G protein-coupled receptors. Benzyl quinolone carboxylic acid (BQCA) is an unprecedented example of a highly selective positive allosteric modulator of the M(1) muscarinic acetylcholine receptor (mACh...

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Dettagli Bibliografici
Autori principali: Yeatman, Holly R., Lane, J. Robert, Choy, Kwok Ho Christopher, Lambert, Nevin A., Sexton, Patrick M., Christopoulos, Arthur, Canals, Meritxell
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140939/
https://ncbi.nlm.nih.gov/pubmed/24753247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536672
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