Mechanistic Insights into Allosteric Structure-Function Relationships at the M(1) Muscarinic Acetylcholine Receptor

Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric modulator (PAM) for the M(1) muscarinic acetylcholine receptor (mAChR), but it possesses low affinity for the allosteric site on the receptor. More recent drug discovery efforts identified 3-((1S,2S)-2-hydroxycy...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., López, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246120/
https://ncbi.nlm.nih.gov/pubmed/25326383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604967
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