Differential A(1)-adenosine receptor reserve for inhibition of cyclic AMP accumulation and G-protein activation in DDT(1) MF-2 cells

Por Baker, Stephen P, Scammells, Peter J, Belardinelli, Luiz
Publicado em 2000

Development of M(1) mAChR Allosteric and Bitopic Ligands: Prospective Therapeutics for the Treatment of Cognitive Deficits

Por Davie, Briana J., Christopoulos, Arthur, Scammells, Peter J.
Publicado em 2013

A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation

Por Canals, Meritxell, Lane, J. Robert, Wen, Adriel, Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2012

An Allosteric Modulator of the Adenosine A(1) Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts

Por Butcher, Anna, Scammells, Peter J., White, Paul J., Devine, Shane M., Rose’Meyer, Roselyn B.
Publicado em 2013

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Por Paiardini, Alessandro, Bamert, Rebecca S., Kannan-Sivaraman, Komagal, Drinkwater, Nyssa, Mistry, Shailesh N., Scammells, Peter J., McGowan, Sheena
Publicado no PLoS One (2015)

A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

Por Valant, Celine, Gregory, Karen J., Hall, Nathan E., Scammells, Peter J., Lew, Michael J., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2008

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A(1) adenosine receptor allosteric modulators and antagonists

Por Aurelio, Luigi, Valant, Celine, Figler, Heidi, Flynn, Bernard L., Linden, Joel, Sexton, Patrick M., Christopoulos, Arthur, Scammells, Peter J.
Publicado em 2009

Molecular Mechanisms of Bitopic Ligand Engagement with the M(1) Muscarinic Acetylcholine Receptor

Por Keov, Peter, López, Laura, Devine, Shane M., Valant, Celine, Lane, J. Robert, Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2014

Determination of Adenosine A(1) Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity

Por Stewart, Gregory D., Valant, Celine, Dowell, Simon J., Mijaljica, Dalibor, Devenish, Rodney J., Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2009

Mechanistic Insights into Allosteric Structure-Function Relationships at the M(1) Muscarinic Acetylcholine Receptor

Por Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., López, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Publicado no J Biol Chem (2014)

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

Por Valant, Celine, May, Lauren T., Aurelio, Luigi, Chuo, Chung Hui, White, Paul J., Baltos, Jo-Anne, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur
Publicado em 2014

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK

Por Vinh, Natalie B, Devine, Shane M, Munoz, Lenka, Ryan, Renae M, Wang, Bing H, Krum, Henry, Chalmers, David K, Simpson, Jamie S, Scammells, Peter J
Publicado no ChemistryOpen (2015)

2-Aminothienopyridazines as Novel Adenosine A(1) Receptor Allosteric Modulators and Antagonists

Por Ferguson, Gemma N., Valant, Celine, Horne, James, Figler, Heidi, Flynn, Bernard L., Linden, Joel, Chalmers, David K., Sexton, Patrick M., Christopoulos, Arthur, Scammells, Peter J.
Publicado em 2008

A new mechanism of allostery in a G protein-coupled receptor dimer

Por Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Publicado em 2014

The role of kinetic context in apparent biased agonism at GPCRs

Por Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicado no Nat Commun (2016)