Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D(2) Receptor Creates an Internalization-defective Receptor

Por Clayton, Cecilea C., Donthamsetti, Prashant, Lambert, Nevin A., Javitch, Jonathan A., Neve, Kim A.
Publicado no J Biol Chem (2014)

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

Por Michino, Mayako, Beuming, Thijs, Donthamsetti, Prashant, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Publicado no Pharmacol Rev (2015)

Using bioluminescent resonance energy transfer (BRET) to characterize agonist-induced arrestin recruitment to modified and unmodified G protein-coupled receptors (GPCRs)

Por Donthamsetti, Prashant, Quejada, Jose Rafael, Javitch, Jonathan A., Gurevich, Vsevolod V., Lambert, Nevin A.
Publicado no Curr Protoc Pharmacol (2015)

Amino Acid Architecture That Influences dNTP Insertion Efficiency in Y-Family DNA Polymerase V of E. coli

Por Seo, Kwang Young, Yin, Jun, Donthamsetti, Prashant, Chandani, Sushil, Lee, Chui Hong, Loechler, Edward L.
Publicado em 2009

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Por Donthamsetti, Prashant C., Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A., Isacoff, Ehud Y., Trauner, Dirk
Publicado no J Am Chem Soc (2017)

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Por Michino, Mayako, Donthamsetti, Prashant, Beuming, Thijs, Banala, Ashwini, Duan, Lihua, Roux, Thomas, Han, Yang, Trinquet, Eric, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Publicado em 2013

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Por Donthamsetti, Prashant C., Broichhagen, Johannes, Vyklicky, Vojtech, Stanley, Cherise, Fu, Zhu, Visel, Meike, Levitz, Joshua L., Javitch, Jonathan A., Trauner, Dirk, Isacoff, Ehud Y.
Publicado no J Am Chem Soc (2019)

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

Por Farino, Zachary J., Morgenstern, Travis J., Vallaghe, Julie, Gregor, Nathalie, Donthamsetti, Prashant, Harris, Paul E., Pierre, Nicolas, Freyberg, Robin, Charrier-Savournin, Fabienne, Javitch, Jonathan A., Freyberg, Zachary
Publicado no PLoS One (2016)

Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens

Por Marcott, Pamela F, Gong, Sheng, Donthamsetti, Prashant, Grinnell, Steven G., Nelson, Melissa N., Newman, Amy H, Birnbaumer, Lutz, Martemyanov, Kirill A, Javitch, Jonathan A, Ford, Christopher P
Publicado no Neuron (2018)

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

Por Donthamsetti, Prashant, Gallo, Eduardo F., Buck, David C., Stahl, Edward L., Zhu, Ying, Lane, J. Robert, Bohn, Laura M., Neve, Kim A., Kellendonk, Christoph, Javitch, Jonathan A.
Publicado no Mol Psychiatry (2018)

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Por Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonathan A., Shi, Lei
Publicado em 2012

Optical Control of Lysophosphatidic Acid Signaling

Por Morstein, Johannes, Dacheux, Mélanie A., Norman, Derek D., Shemet, Andrej, Donthamsetti, Prashant C., Citir, Mevlut, Frank, James A., Schultz, Carsten, Isacoff, Ehud Y., Parrill, Abby L., Tigyi, Gabor J., Trauner, Dirk
Publicado no J Am Chem Soc (2020)

A new mechanism of allostery in a G protein-coupled receptor dimer

Por Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Publicado em 2014

The role of kinetic context in apparent biased agonism at GPCRs

Por Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicado no Nat Commun (2016)

High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice

Por Boateng, Comfort A., Bakare, Oluyomi M., Zhan, Jia, Banala, Ashwini K., Burzynski, Caitlin, Pommier, Elie, Keck, Thomas M., Donthamsetti, Prashant, Javitch, Jonathan A., Rais, Rana, Slusher, Barbara S., Xi, Zheng-Xiong, Newman, Amy Hauck
Publicado no J Med Chem (2015)

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

Por Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Publicado no J Med Chem (2016)

Towards understanding the structural basis of partial agonism at the dopamine D(3) receptor

Por Michino, Mayako, Boateng, Comfort A., Donthamsetti, Prashant, Yano, Hideaki, Bakare, Oluyomi M., Bonifazi, Alessandro, Ellenberger, Michael P., Keck, Thomas M., Kumar, Vivek, Zhu, Clare, Verma, Ravi, Deschamps, Jeffrey R., Javitch, Jonathan A., Newman, Amy Hauck, Shi, Lei
Publicado no J Med Chem (2017)

Optical Control of Sphingosine-1-Phosphate Formation and Function

Por Morstein, Johannes, Hill, Rose Z., Novak, Alexander J. E., Feng, Suihan, Norman, Derek D., Donthamsetti, Prashant C., Frank, James A., Harayama, Takeshi, Williams, Benjamin M., Parrill, Abby L., Tigyi, Gabor J., Riezman, Howard, Isacoff, Ehud Y., Bautista, Diana M., Trauner, Dirk
Publicado no Nat Chem Biol (2019)

New roles for dopamine D(2) and D(3) receptors in pancreatic beta cell insulin secretion

Por Farino, Zachary J., Morgenstern, Travis J., Maffei, Antonella, Quick, Matthias, De Solis, Alain J., Wiriyasermkul, Pattama, Freyberg, Robin J., Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P., Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V., Kellendonk, Christoph, Schwartz, Gary J., Sibley, David R., Schmauss, Claudia, Zeltser, Lori M., Moore, Holly, Harris, Paul E., Javitch, Jonathan A., Freyberg, Zachary
Publicado no Mol Psychiatry (2019)