Towards understanding the structural basis of partial agonism at the dopamine D(3) receptor

Both dopamine D(3) receptor (D(3)R) partial agonists and antagonists have been implicated as potential medications for substance use disorders. In contrast to antagonists, partial agonists may cause fewer side effects since they maintain some dopaminergic tone and may be less disruptive to normal ne...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Michino, Mayako, Boateng, Comfort A., Donthamsetti, Prashant, Yano, Hideaki, Bakare, Oluyomi M., Bonifazi, Alessandro, Ellenberger, Michael P., Keck, Thomas M., Kumar, Vivek, Zhu, Clare, Verma, Ravi, Deschamps, Jeffrey R., Javitch, Jonathan A., Newman, Amy Hauck, Shi, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563258/
https://ncbi.nlm.nih.gov/pubmed/27983845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01148
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