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Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D(2) Receptor (D(2)R) Biased Agonism
The development of bivalent ligands has attracted interest as a way to potentially improve the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct receptor binding sites simultaneously can allow the selective activation of specific G-protein dependent or β-a...
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| Pubblicato in: | J Med Chem |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7594663/ https://ncbi.nlm.nih.gov/pubmed/28300398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01875 |
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