Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

[Image: see text] Novel 1-, 5-, and 8-substituted analogues of sumanirole (1), a dopamine D(2)/D(3) receptor (D(2)R/D(3)R) agonist, were synthesized. Binding affinities at both D(2)R and D(3)R were higher when determined in competition with the agonist radioligand [(3)H]7-hydroxy-N,N-dipropyl-2-amin...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915350/
https://ncbi.nlm.nih.gov/pubmed/27035329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01612
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