High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice

[Image: see text] The dopamine D(3) receptor (D(3)R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D(3)R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailabili...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Boateng, Comfort A., Bakare, Oluyomi M., Zhan, Jia, Banala, Ashwini K., Burzynski, Caitlin, Pommier, Elie, Keck, Thomas M., Donthamsetti, Prashant, Javitch, Jonathan A., Rais, Rana, Slusher, Barbara S., Xi, Zheng-Xiong, Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937837/
https://ncbi.nlm.nih.gov/pubmed/26203768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00776
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