Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the development of D3R-selective compounds challenging. H...

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Bibliografiske detaljer
Main Authors: Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonathan A., Shi, Lei
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415572/
https://ncbi.nlm.nih.gov/pubmed/22632094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300482h
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