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Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor
The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the development of D3R-selective compounds challenging. H...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415572/ https://ncbi.nlm.nih.gov/pubmed/22632094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300482h |
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