Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the development of D3R-selective compounds challenging. H...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonathan A., Shi, Lei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415572/
https://ncbi.nlm.nih.gov/pubmed/22632094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300482h
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