Subtype Selectivity of Dopamine Receptor Ligands: Insights from Structure and Ligand-Based Methods

Por Wang, Qi, Mach, Robert H., Luedtke, Robert R., Reichert, David E.
Publicado em 2010

Dopamine D3 Receptor Selective Ligands with Varying Intrinsic Efficacies at Adenylyl Cyclase Inhibition and Mitogenic Signaling Pathways

Por Taylor, Michelle, Grundt, Peter, Griffin, Suzy A., Newman, Amy Hauck, Luedtke, Robert R.
Publicado em 2010

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, Function and SAR

Por Grundt, Peter, Husbands, Sarah Little Jane, Luedtke, Robert R., Taylor, Michelle, Newman, Amy Hauck
Publicado em 2006

Evaluation of the D3 Dopamine Receptor Selective Antagonist PG01037 on L-Dopa Dependent Abnormal Involuntary Movements in Rats

Por Kumar, Rakesh, Riddle, Lindsay, Griffin, Suzy A., Grundt, Peter, Newman, Amy Hauck, Luedtke, Robert R.
Publicado em 2009

Structure–Activity Relationships for a Novel Series of Dopamine D2-like Receptor Ligands Based on N-Substituted 3-Aryl-8-azabicyclo[3.2.1]octan-3-ol

Por Paul, Noel M., Taylor, Michelle, Kumar, Rakesh, Deschamps, Jeffrey R., Luedtke, Robert R., Newman, Amy Hauck
Publicado em 2008

Evaluation of the D3 Dopamine Receptor Selective Agonist/Partial Agonist PG01042 on L-Dopa Dependent Animal Involuntary Movements in Rats

Por Riddle, Lindsay R., Kumar, Rakesh, Griffin, Suzy A., Grundt, Peter, Newman, Amy Hauck, Luedtke, Robert R.
Publicado em 2010

Characterization of [(3)H]LS-3-134, a Novel Arylamide Phenylpiperazine D3 Dopamine Receptor Selective Radioligand

Por Rangel-Barajas, Claudia, Malik, Maninder, Taylor, Michelle, Neve, Kim A., Mach, Robert H., Luedtke, Robert R.
Publicado no J Neurochem (2014)

Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine

Por Rangel-Barajas, Claudia, Estrada-Sánchez, Ana María, Barton, Scott J., Luedtke, Robert R., Rebec, George V.
Publicado no Neuropharmacology (2016)

Effect of Cyclosporin A on the Uptake of D(3)-Selective PET Radiotracers in Rat Brain

Por Tu, Zhude, Li, Shihong, Xu, Jinbin, Chu, Wenhua, Jones, Lynne A., Luedtke, Robert R., Mach, Robert H.
Publicado em 2011

Synthesis and Characterization of Selective Dopamine D(2) Receptor Antagonists. 2. Azaindole, Benzofuran, and Benzothiophene Analogs of L-741,626

Por Vangveravong, Suwanna, Taylor, Michelle, Xu, Jinbin, Cui, Jinquan, Calvin, Wesley, Babic, Sonja, Luedtke, Robert R., Mach, Robert H.
Publicado em 2010

Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?

Por Karimi, Morvarid, Moerlein, Stephen M., Videen, Tom O., Luedtke, Robert R., Taylor, Michelle, Mach, Robert H., Perlmutter, Joel S.
Publicado em 2010

Synthesis and Pharmacological Evaluation of Fluorine Containing D(3) Dopamine Receptor Ligands

Por Tu, Zhude, Li, Shihong, Cui, Jinquan, Xu, Jinbin, Taylor, Michelle, Ho, David, Luedtke, Robert R., Mach, Robert H.
Publicado em 2011

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D(3) dopamine receptor selective ligands()

Por Tu, Zhude, Li, Shihong, Li, Aixiao, Taylor, Michelle, Ho, David, Malik, Maninder, Luedtke, Robert R., Mach, Robert H.
Publicado em 2013

N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)-butyl)-heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antag...

Por Newman, Amy Hauck, Grundt, Peter, Cyriac, George, Deschamps, Jeffrey R., Taylor, Michelle, Kumar, Rakesh, Ho, David, Luedtke, Robert R.
Publicado em 2009

Using prepulse inhibition to detect functional D3 receptor antagonism: Effects of WC10 and WC44

Por Weber, Martin, Chang, Wei-Li, Durbin, John P., Park, Paula E., Luedtke, Robert R., Mach, Robert H., Swerdlow, Neal R.
Publicado em 2009

Synthesis and characterization of selective dopamine D(2) receptor ligands using aripiprazole as the lead compound

Por Vangveravong, Suwanna, Zhang, Zhanbin, Taylor, Michelle, Bearden, Melissa, Xu, Jinbin, Cui, Jinquan, Wang, Wei, Luedtke, Robert R., Mach, Robert H.
Publicado em 2011

Neuroprotective effects of high affinity sigma 1 receptor selective compounds

Por Luedtke, Robert R., Perez, Evelyn, Yang, Shao-Hua, Liu, Ran, Vangveravong, Suwanna, Tu, Zhude, Mach, Robert H., Simpkins, James W.
Publicado em 2011

Evaluation of D2 and D3 Dopamine Receptor Selective Compounds on L-Dopa Dependent Abnormal Involuntary Movements in Rats

Por Kumar, Rakesh, Riddle, Lindsay R., Griffin, Suzy A., Chu, Wenjua, Vangveravong, Suwanna, Neisewander, Janet, Mach, Robert H., Luedtke, Robert R.
Publicado em 2009

Evaluation of N-Phenyl Homopiperazine Analogs as Potential Dopamine D(3) Receptor Selective Ligands

Por Li, Aixiao, Mishra, Yogesh, Malik, Maninder, Wang, Qi, Li, Shihong, Taylor, Michelle, Reichert, David E., Luedtke, Robert R., Mach, Robert H.
Publicado em 2013

Synthesis, Pharmacological Evaluation and Molecular Modeling Studies of Triazole Containing Dopamine D(3) Receptor Ligands

Por Peng, Xin, Wang, Qi, Mishra, Yogesh, Xu, Jinbin, Reichert, David E., Malik, Maninder, Taylor, Michelle, Luedtke, Robert R., Mach, Robert H.
Publicado no Bioorg Med Chem Lett (2014)