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Dopamine D3 Receptor Selective Ligands with Varying Intrinsic Efficacies at Adenylyl Cyclase Inhibition and Mitogenic Signaling Pathways
A panel of eight structurally related pairs of 2,3-dichloro and 2-methoxy substituted 4-phenylpiperazines with nanomolar affinity and selectivity at D3 dopamine receptors has been synthesized. Compounds in which a heterocyclic (2-phenyl pyridyl, 3-phenyl pyridyl, benzothiophen or benzofuran) moiety...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821045/ https://ncbi.nlm.nih.gov/pubmed/19924694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20725 |
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