Synthesis and Pharmacological Evaluation of Fluorine Containing D(3) Dopamine Receptor Ligands

A series of fluorine containing N-(2-methoxyphenyl)piperazine and N-(2-fluoroethoxy)piperazine analogues were synthesized and their affinities for human dopamine D(2), D(3) and D(4) receptors were determined. Radioligand binding studies identified five compounds, 18a, 20a, 20c, 20e and 21e, which bi...

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Bibliographic Details
Main Authors: Tu, Zhude, Li, Shihong, Cui, Jinquan, Xu, Jinbin, Taylor, Michelle, Ho, David, Luedtke, Robert R., Mach, Robert H.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066655/
https://ncbi.nlm.nih.gov/pubmed/21348515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101323b
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