Synthesis and Evaluation of Isatin Analogs as Caspase-3 Inhibitors: Introduction of a Hydrophilic Group Increases Potency in a Whole Cell Assay

von Chu, Wenhua, Rothfuss, Justin, Zhou, Dong, Mach, Robert H.
Veröffentlicht 2011

Copper-Mediated Nucleophilic Radiobromination of Aryl Boron Precursors: Convenient Preparation of a Radiobrominated PARP-1 Inhibitor

von Zhou, Dong, Chu, Wenhua, Voller, Thomas, Katzenellenbogen, John A
Veröffentlicht in Tetrahedron Lett (2018)

Highly efficient click labeling using 2-[(18)F]fluoroethyl azide and synthesis of an (18)F N-hydroxysuccinimide ester as conjugation agent

von Zhou, Dong, Chu, Wenhua, Dence, Carmen S., Mach, Robert H., Welch, Michael J.
Veröffentlicht 2012

Evaluation of Aromatic Radiobromination by Nucleophilic Substitution using Diaryliodonium Salt Precursors

von Zhou, Dong, Kim, Sung Hoon, Chu, Wenhua, Voller, Thomas, Katzenellenbogen, John A
Veröffentlicht in J Labelled Comp Radiopharm (2017)

Facile purification and click labeling with 2-[(18)F]fluoroethyl azide using solid phase extraction cartridges

von Zhou, Dong, Chu, Wenhua, Peng, Xin, McConathy, Jonathan, Mach, Robert H., Katzenellenbogen, John A.
Veröffentlicht in Tetrahedron Lett (2014)

New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ(2) receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosens...

von Chu, Wenhua, Xu, Jinbin, Zhou, Dong, Zhang, Fanjie, Jones, Lynne A., Wheeler, Kenneth T., Mach, Robert H.
Veröffentlicht 2008

Effect of Cyclosporin A on the Uptake of D(3)-Selective PET Radiotracers in Rat Brain

von Tu, Zhude, Li, Shihong, Xu, Jinbin, Chu, Wenhua, Jones, Lynne A., Luedtke, Robert R., Mach, Robert H.
Veröffentlicht 2011

Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

von Chen, Delphine L., Engle, Jacquelyn T., Griffin, Elizabeth A., Miller, J. Philip, Chu, Wenhua, Zhou, Dong, Mach, Robert H.
Veröffentlicht in Mol Imaging Biol (2015)

Synthesis, [(18)F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography

von Zhou, Dong, Chu, Wenhua, Xu, Jinbin, Jones, Lynne A., Peng, Xin, Li, Shihong, Chen, Delphine L., Mach, Robert H.
Veröffentlicht 2014

Preliminary evaluation of a novel (18)F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer

von Zhou, Dong, Xu, Jinbin, Mpoy, Cedric, Chu, Wenhua, Kim, Sung Hoon, Li, Huifangjie, Rogers, Buck E., Katzenellenbogen, John A.
Veröffentlicht in Nucl Med Biol (2018)

Synthesis and Structure-Activity Relationship Studies of Conformationally Flexible Tetrahydroisoquinolinyl Triazole Carboxamide and Triazole Substituted Benzamide Analogues as σ(2)...

von Bai, Suping, Li, Shihong, Xu, Jinbin, Peng, Xin, Sai, Kiran, Chu, Wenhua, Tu, Zhude, Zeng, Chenbo, Mach, Robert H.
Veröffentlicht in J Med Chem (2014)

Functional assays to define agonists and antagonists of the sigma-2 receptor

von Zeng, Chenbo, Rothfuss, Justin M., Zhang, Jun, Vangveravong, Suwanna, Chu, Wenhua, Li, Shihong, Tu, Zhude, Xu, Jinbin, Mach, Robert H.
Veröffentlicht 2013

[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl]benzamide, a Selective Radioligand for Dopamine D(3) receptors. II. Quantitative Analysis of Dopamine D(3) and...

von Xu, Jinbin, Hassanzadeh, Babak, Chu, Wenhua, Tu, Zhude, Jones, Lynne A., Luedtke, Robert R., Perlmutter, Joel S., Mintun, Mark A., Mach, Robert H.
Veröffentlicht 2009

[(3)H]4-(Dimethylamino)-N-(4-(4-(2-Methoxyphenyl)Piperazin-1-yl)-Butyl)Benzamide: A Selective Radioligand for Dopamine D(3) receptors. II. Quantitative Analysis of Dopamine D(3) an...

von XU, JINBIN, HASSANZADEH, BABAK, CHU, WENHUA, TU, ZHUDE, JONES, LYNNE A., LUEDTKE, ROBERT R., PERLMUTTER, JOEL S., MINTUN, MARK A., MACH, ROBERT H.
Veröffentlicht 2010

[(18)F]- and [(11)C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging of apoptosis in Fas-treated...

von Zhou, Dong, Chu, Wenhua, Chen, Delphine L., Wang, Qi, Reichert, David E., Rothfuss, Justin, D'Avignon, Andre, Welch, Michael J., Mach, Robert H.
Veröffentlicht 2009

Development of a PET Radiotracer for Noninvasive Imaging of the Reactive Oxygen Species, Superoxide, in vivo

von Chu, Wenhua, Chepetan, Andre, Zhou, Dong, Shoghi, Kooresh I., Xu, Jinbin, Dugan, Laura L., Gropler, Robert J., Mintun, Mark A., Mach, Robert H.
Veröffentlicht 2014

PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116

von Thukkani, Arun K, Shoghi, Kooresh I, Zhou, Dong, Xu, Jinbin, Chu, Wenhua, Novak, Eric, Chen, Delphine L, Gropler, Robert J, Mach, Robert H
Veröffentlicht in Am J Nucl Med Mol Imaging (2016)

Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1

von Chen, Huaping, Afrin, Sadia, Guo, Yingqiu, Chu, Wenhua, Benzinger, Tammie L.S., Rogers, Buck E., Garbow, Joel R., Perlmutter, Joel S., Zhou, Dong, Xu, Jinbin
Veröffentlicht in Int J Mol Sci (2020)

Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy

von Han Byung, Zhou Meng-liang, Vellimana Ananth K, Milner Eric, Kim David H, Greenberg Jacob K, Chu Wenhua, Mach Robert H, Zipfel Gregory J
Veröffentlicht 2011-12-01

Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist

von Xu, Jinbin, Vangveravong, Suwanna, Li, Shihong, Fan, Jinda, Jones, Lynne A., Cui, Jinquan, Wang, Ruike, Tu, Zhude, Chu, Wenhua, Perlmutter, Joel S., Mach, Robert H.
Veröffentlicht 2013