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New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ(2) receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents
A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs were synthesized. Among them, WC-26 and WC-59 were identified as the most potent σ(2) receptor ligands (K(i) = 2.58 and 0.82 nM, respectively) with high selectivity against σ(1) (K(i) of σ(1)/σ(2) ratio = 557 and 2,087,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670245/ https://ncbi.nlm.nih.gov/pubmed/19119012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.025 |
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