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[(18)F]- and [(11)C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging of apoptosis in Fas-treated mice
The radiolabeled isatin sulfonamide caspase-3 inhibitor, [(18)F]2 (WC-II-89), is a potential PET radiotracer for noninvasive imaging of apoptosis. The radiolabeling mechanism was studied by (13)C NMR, ESI/MS, and computational calculations. It was found that the high electrophilicity of the C3 carbo...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075237/ https://ncbi.nlm.nih.gov/pubmed/19300818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b819024k |
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