Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66

[Image: see text] The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H-indole-2-carboxamide ((R)-PG648) is described. The same chiral secondary alcohol intermediate was used to prepare the enantiomers o...

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Detalhes bibliográficos
Main Authors: Kumar, Vivek, Banala, Ashwini K., Garcia, Erick G., Cao, Jianjing, Keck, Thomas M., Bonifazi, Alessandro, Deschamps, Jeffery R., Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060923/
https://ncbi.nlm.nih.gov/pubmed/24944737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500006v
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