Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66

[Image: see text] The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H-indole-2-carboxamide ((R)-PG648) is described. The same chiral secondary alcohol intermediate was used to prepare the enantiomers o...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Kumar, Vivek, Banala, Ashwini K., Garcia, Erick G., Cao, Jianjing, Keck, Thomas M., Bonifazi, Alessandro, Deschamps, Jeffery R., Newman, Amy Hauck
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060923/
https://ncbi.nlm.nih.gov/pubmed/24944737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500006v
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller