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Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D(3) Receptor Antagonists
[Image: see text] We report a class of potent and selective dopamine D(3) receptor antagonists based upon tranylcypromine. Although tranylcypromine has a low affinity for the rat D(3) receptor (K(i) = 12.8 μM), our efforts have yielded (1R,2S)-11 (CJ-1882), which has K(i) values of 2.7 and 2.8 nM at...
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| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4216217/ https://ncbi.nlm.nih.gov/pubmed/24848155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401798r |
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