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Pramipexole Derivatives as Potent and Selective Dopamine D(3) Receptor Agonists with Improved Human Microsomal Stability
We report herein the synthesis and evaluation of a series of new pramipexole derivatives as highly potent and selective dopamine-3 (D(3)) receptor agonists. A number of these new compounds bind to the D(3) receptor with subnanomolar affinities and show excellent selectivity (>10,000) for the D(3)...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4277207/ https://ncbi.nlm.nih.gov/pubmed/25338762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402398 |
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