Pramipexole Derivatives as Potent and Selective Dopamine D(3) Receptor Agonists with Improved Human Microsomal Stability

We report herein the synthesis and evaluation of a series of new pramipexole derivatives as highly potent and selective dopamine-3 (D(3)) receptor agonists. A number of these new compounds bind to the D(3) receptor with subnanomolar affinities and show excellent selectivity (>10,000) for the D(3)...

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Опубликовано в: :ChemMedChem
Главные авторы: Chen, Jianyong, Jiang, Cheng, Levant, Beth, Li, Xiaoqin, Zhao, Ting, Wen, Bo, Luo, Ruijuan, Sun, Duxin, Wang, Shaomeng
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277207/
https://ncbi.nlm.nih.gov/pubmed/25338762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402398
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