Wird geladen...
Design, Synthesis and Evaluation of Potent and Selective Ligands for the Dopamine 3 (D(3)) Receptor with a Novel in vivo Behavioral Profile
A series of compounds structurally related to pramipexole were designed, synthesized and evaluated as ligands for the dopamine 3 (D(3)) receptor. Compound 12 has a K(i) value of 0.41 nM to D(3) and a selectivity of >30,000- and 800-fold over the D(1)-like and D(2) receptors, respectively. Our in...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662387/ https://ncbi.nlm.nih.gov/pubmed/18785726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800471h |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|