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Design, Synthesis and Evaluation of Potent and Selective Ligands for the Dopamine 3 (D(3)) Receptor with a Novel in vivo Behavioral Profile
A series of compounds structurally related to pramipexole were designed, synthesized and evaluated as ligands for the dopamine 3 (D(3)) receptor. Compound 12 has a K(i) value of 0.41 nM to D(3) and a selectivity of >30,000- and 800-fold over the D(1)-like and D(2) receptors, respectively. Our in...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662387/ https://ncbi.nlm.nih.gov/pubmed/18785726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800471h |
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