The binding sites for cocaine and dopamine in the dopamine transporter overlap

Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT....

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Beuming, Thijs, Kniazeff, Julie, Bergmann, Marianne L, Shi, Lei, Gracia, Luis, Raniszewska, Klaudia, Newman, Amy Hauck, Javitch, Jonathan A, Weinstein, Harel, Gether, Ulrik, Loland, Claus J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692229/
https://ncbi.nlm.nih.gov/pubmed/18568020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2146
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky