The binding sites for cocaine and dopamine in the dopamine transporter overlap

Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT....

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Detaylı Bibliyografya
Asıl Yazarlar: Beuming, Thijs, Kniazeff, Julie, Bergmann, Marianne L, Shi, Lei, Gracia, Luis, Raniszewska, Klaudia, Newman, Amy Hauck, Javitch, Jonathan A, Weinstein, Harel, Gether, Ulrik, Loland, Claus J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692229/
https://ncbi.nlm.nih.gov/pubmed/18568020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2146
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