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The binding sites for cocaine and dopamine in the dopamine transporter overlap
Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT....
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692229/ https://ncbi.nlm.nih.gov/pubmed/18568020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2146 |
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