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Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

The dopamine transporter (DAT), a member of the neurotransmitter:sodium symporter family, mediates the reuptake of dopamine at the synaptic cleft. DAT is the primary target for psychostimulants such as cocaine and amphetamine. We previously demonstrated that cocaine binding and dopamine transport al...

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Bibliographic Details
Main Authors: Dehnes, Yvette, Shan, Jufang, Beuming, Thijs, Shi, Lei, Weinstein, Harel, Javitch, Jonathan A.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058377/
https://ncbi.nlm.nih.gov/pubmed/24576496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2014.02.003
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