Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Donthamsetti, Prashant C., Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A., Isacoff, Ehud Y., Trauner, Dirk
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942546/
https://ncbi.nlm.nih.gov/pubmed/29166564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07659
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