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Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Donthamsetti, Prashant C., Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A., Isacoff, Ehud Y., Trauner, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942546/
https://ncbi.nlm.nih.gov/pubmed/29166564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07659
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