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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

[Image: see text] G protein-coupled receptors (GPCRs) are the most common targets of drug discovery. However, the similarity between related GPCRs combined with the complex spatiotemporal dynamics of receptor activation in vivo has hindered drug development. Photopharmacology offers the possibility...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Autores principales: Donthamsetti, Prashant, Konrad, David B., Hetzler, Belinda, Fu, Zhu, Trauner, Dirk, Isacoff, Ehud Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227462/
https://ncbi.nlm.nih.gov/pubmed/34115935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c02586
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