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Using bioluminescent resonance energy transfer (BRET) to characterize agonist-induced arrestin recruitment to modified and unmodified G protein-coupled receptors (GPCRs)
G protein-coupled receptors (GPCRs) represent (~)25% of current drug targets. Ligand binding to these receptors activates G proteins and arrestins, which are involved in differential signaling pathways. Functionally selective or biased ligands activate one of these two pathways and may be superior m...
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| Udgivet i: | Curr Protoc Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4583203/ https://ncbi.nlm.nih.gov/pubmed/26331887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471141755.ph0214s70 |
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